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However, there are some indirect evidences supporting that inhibition of HDAC by VPA can enable methylated DNA to be more accessible to DNA demethylase, leading to DNA demethylation [135], which suggests that the induction of the methylation of Scn3a promoter by VPA is likely to be affected by the regulation of HDAC

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van Triest M, Bos JL (2004) Pull-down assays for guanoside 5-triphosphate-bound ras-like guanosine 5-triphosphatases