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Safety and efficacy of liraglutide, 3.0 mg, once daily vs placebo in patients with poor weight loss following metabolic surgery: the BARI-OPTIMISE randomized clinical trial

However, because BPC-157 and TB-500 promote angiogenesis (new blood vessel formation) and healing, theoretical concerns exist about providing blood supply to existing tumors

Additionally, researchers found that GLP-1R neurons in the area of the Interestingly, activation of the area postrema GLP-1R neurons causes nausea, but activation of nucleus tractus solitarius GLP-1R neurons causes satiety without nausea, Alhadeff explained

Combining these two can compound GI distress, making it harder to distinguish which agent is responsible and potentially reducing tolerability and compliance