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The respective daily dosage was established by the appropriate combination of 750 mg GPLC capsules and 750 mg capsules of cellulose (the GPLC and cellulose capsules were visually identical)

121 Participants were randomly assigned to receive canagliflozin (100300 mg) or placebo and were followed for a mean of 3.6 years (median 2.4 years)

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