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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant

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Compromised Detoxification The liver uses glutathione extensively for detoxification processes, specifically in phase II of liver detox, where harmful substances like heavy metals, environmental toxins, and metabolic waste products are made more water-soluble for easier elimination

L-ornithine-L-aspartate L-ornithine-L-aspartate is a combination of two amino acids naturally present in the diet: L-ornithine and L-aspartate , found in certain plant and animal protein-rich sources

Figure 11 Healy et al