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Grandjean et al concluded through their meta-analysis of eight trials that oral delivery of NAC at doses ranging from 400 to 1200 mg per day to as little as 600 mg three times per week proved to be superior to placebo in the treatment of chronic bronchitis

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Crupi R, Impellizzeri D, Cuzzocrea S

[18] Glutathione S-transferase uses GSH to clean up various metabolites, xenobiotics, and electrophiles to mercapturates for excretion