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Other possible contributors include hormonal shifts, changes in insulin signaling, metabolic stress, and possibly effects on the hair follicle itself, he says

In fact, HIEC proliferation and TEER significantly increases when co-cultured simultaneously with both cell types, advocating for the importance of developing complex OoC systems that can generate more biologically relevant outputs

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While some evidence suggests protective effects, rapid weight loss and reduced nutrient intake can compromise bone density

This modulation appears selective, as AOD 9604 does not activate the growth hormone receptor or induce downstream IGF-1 signaling