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In a retrospective analysis of 177 patients on oral semaglutide, weight loss velocity decelerates sharply after 3 months from 1.99 kg/month in the first month to 0.18 kg/month between months 6 and 12 and a 23% weight rebound is already measurable by month 18 (Makkar et al., 2026)

Additionally, some discrepancies may be explained by our findings, which show that mRNA co-localization of LepR and GLP-1R varies depending on the anatomical location within the DMH, with a higher overlap percentage in the caudal part of the DMH than the rostral part [69]

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