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In the unilateral ureteral obstruction model, liraglutide suppressed TGF- expression and downstream Smad3 and ERK1/2 signalling, resulting in reduced tubulointerstitial collagen accumulation and improved histological fibrosis scores [56]

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These include people who: Are pregnant or planning to become pregnant Are breastfeeding or planning to breastfeed Have unexplained weight loss Have severe or persistent diarrhea Have chronic vomiting Have dark stools Have ongoing fatigue (anemia) Have difficulty swallowing Have a history of liver problems Patients taking Pantoprazole who have low magnesium should also be extra cautious

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Some people also see a small increase in blood pressure as they come off of a GLP-1 RA