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This is an ideal guide for rheumatologists and primary care physicians treating patients with Ehlers-Danlos and hypermobility syndromes, and patients and their loved ones in understanding their disease and disorders and the associated treatments and therapies

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Treatment by C21, an AT 2 R ligand, reduces fibrosis, hypertrophy of the right heart ventricle, and expression of pro-inflammatory cytokines leading to cardiac function improvement, moreover it can improve COVID-19-induced lung injury, lung dysfunction, and associated cardiopulmonary pathology (150)