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Another potential limitation of this study is that we only used one assay kit to quantify levels of GSH in our plasma samples
However, significant limitations include operational complexity, time-consuming procedures requiring specialized expertise, and reliance on lag phase quantification
Using bulk RNA-sequencing data, we found that lower expression of mevalonate decarboxylase ( MVD ), mevalonate kinase ( MVK ), farnesyl diphosphate synthase ( FDPS ), and farnesyl diphosphate farnesyltransferase 1 ( FDFT1 ) was independently associated with improved survival (Figure 1CD)
Abbreviations ALD Alcoholic liver disease BMDM Bone marrow-derived macrophage BMP Bone morphogenetic protein CDT Carbohydrate-deficient transferrin C/EBP CCAAT/enhancer-binding protein CP Ceruloplasmin DAMPs Damage-associated molecular patterns DcytB Duodenal cytochrome b DMT1 Divalent metal transporter-1 EGF Epidermal growth factor EPO Erythropoietin ERFE Erythroferrone FPN Ferroportin GLUT4 Glucose transporter 4 GPX4 Glutathione peroxidase 4 GSH Glutathione HCP1 Heme carrier protein-1 HIFs Hypoxia-inducible factors HJV Hemojuvelin HO1 Heme oxygenase 1 HSCs Hepatic stellate cells HGF Hepatocyte growth factor 4-HNE 4-Hydroxy-2-nonenal IL6 Interleukin 6 IL1 Interleukin 1 IL22 Interleukin 22 IRE Iron-responsive element IRPs Iron regulatory proteins IRS1 Insulin receptor substrate 1 JAK2 Janus kinase 2 KCs Kupffer cells LCN2 Lipocalin-2 LPS Lipopolysaccharide NAC N -Acetylcysteine NAFLD Nonalcoholic fatty liver disease NASH Nonalcoholic steatohepatitis NF-B Nuclear factor-B NLRP3 NOD-like receptor family pyrin domain containing 3 NRF2 Nuclear factor erythroid 2-related factor 2 PDGFR Platelet-derived growth factor receptor ROS Reactive oxygen species SIRT1 Sirtuin1 SMA Smooth muscle -actin STAT3 Signal transducers and activators of transcription 3 TS Transferrin saturation TfR Transferrin receptor TNF Tumor necrosis factor Author contributions TZ conceived the concept of the manuscript
