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Gastrointestinal effects These were by far the most commonly reported side effects, and they're the ones most people will want to know about

Triple-hormone-receptor agonist retatrutide for obesity: a Phase 2 trial

Researchers should use one compound at a time

The most commonly reported effects include injection site reactions (redness, mild swelling, itching), joint pain or stiffness, numbness or tingling in the extremities (paresthesia), headaches, and mild fluid retention

Orforglipron also reportedly has a simpler production process than injected GLP-1 drugs such as Ozempic and tirzepatide (sold as Mounjaro) and does not require cold storage factors that could help improve access to the drug if it is approved for use