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Studies show that one night of total sleep deprivation in humans reduced plasma GSH from 4.58 to 3.46, indicating systemic redox imbalance

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This multi-axis neuroendocrine regulatory profile positions DSIP as a broad hypothalamic-pituitary axis modulator, not merely a sleep-specific peptide, and makes it a research tool for studying the neuroendocrine consequences of altered sleep homeostasis and circadian rhythm disruption

Holstein SA, Hohl RJ

Marin-Casad, R., Tobajas, Y., Antoln, A., Negra, T., Connolly, A., & Alcaide-Hidalgo, J