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This can result in infertility issues

10.1016/j.jpba.2024.116525 19 GrahamM

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Moreover, multiple studies show that A is capable of generating free radicals that mediate neuron degeneration and death (Cheignon et al., 2017)

Finally, the orally bioavailable class III c-MET allosteric inhibitor tivantinib (ARQ197, Daiichi-Sankyo, Tokyo, Japan), which binds to an inactive dephosphorylated c-MET conformation, stabilizing it and hence blocking its downstream signaling [20, 125], has been extensively investigated in several cancer types, including HCC, CRC, NSCLC, breast, and GI cancers [126], although results have been disappointing so far