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In T2DM patients, the average change in HbA1c was 2.1% with a dose of 45 mg of orforglipron (compared to dulaglutide and placebo), and nearly half of the participants achieved more than a 10% reduction in body weight in a 26-week phase 2 trial [108]

This treatment is safe for all skin types, has no downtime, and can be used as a maintenance therapy alongside other medical treatments for melasma

rather, it underscores the necessity for more robust, high-quality, and standardized evidence to substantiate their routine application in clinical practice

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