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In a sensitivity analysis restricted to placebo-controlled ALC monotherapy trials (4 studies), the pooled estimate also favored ALC (SMD 2.41, 95% CI 4.43 to 0.39

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Crucially, -carotene is predicted to cross the bloodbrain barrier (Penetrable, Table 4)supported by molecular dynamics simulations of carotenoidmembrane interactions 72 whereas doxorubicins polar structure precludes CNS penetration ("Non-Penetrable", Table 4)