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The net effect is to balance the level of glucose metabolism in response to excess glucose influx

The review addresses translational challenges including workflow constraints, lack of standardization, limited external validation, and cost-effectiveness issues, positioning multi-omics biomarkers within clinically defensible scenarios, such as recurrent implantation failure with euploid embryos and embryo selection under discordant morphological signals, where integration may add actionable value

However, here, we focus solely on the key features we believe a differentiated therapeutic for obesity asset would contain