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For most people the real question is whether the patch itself creates meaningful weight loss, and the honest answer is that there is no strong clinical evidence that typical consumer patches deliver medication level effects through the skin

One study showed decreased levels in post-bariatric surgery patients, but this high-risk group had multiple confounding factors

References Rivas S, Pandya AG

We previously investigated how gastrointestinal distension regulates appetite and energy homeostasis using the inflating stomach formulation (ISF), a carbonated solution containing pectin that forms stable gel bubbles under acidic conditions in the stomach

An elevated plus maze (EPM) is a cross-shaped maze with two closed and two open arms installed at a height of 50 cm