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10.1152/ajprenal.1999.276.5.F777 4 DainiakM

Key Points Summary Thyroid and Metabolism: The thyroid regulates metabolism via T4 and T3 hormones, essential for energy (ATP) production

However, given that pyridoxine is a cocatalyst of many enzymatic processes involved in amino acid metabolisms, such as racemization and decarboxylation, our results do not exclude that pyridoxine may also confer neuroprotection through other undiscovered mechanisms

Subsequent interest in AOD-9604 has been limited to niche research areas, particularly osteoarthritis, where intra-articular injection might bypass systemic bioavailability limitations

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