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An alternative hypothesis was proposed by Koch and collaborators

Dopamine, which acts as a neurotransmitter in the CNS is well known to not cross the BBB [68] due to lack of specific transporter and active metabolism in brain endothelial cells

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Research suggests it may play an important role in: Neurodegenerative diseases Such as Parkinsons and Alzheimers, where oxidative stress contributes to nerve cell damage