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Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(736) amide, petide histidine methionine and is responsible for their degradation in human serum

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A recent study reported that GLP-1RA liraglutide ameliorated DSS-induced colitis by modulating ILC3s and that GLP-1RA promoted IL-22 production by ILC3s, which ameliorated histological damage [185]

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However, it may cause allergic reactions, such as itching, headaches, and joint pain, or gastrointestinal symptoms like nausea or diarrhea