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Semaglutide and tirzepatide target appetite regulation, gastric emptying, and blood sugar signaling

In the gut, it slows gastric emptying through vagal and smooth muscle effects

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That renal hypoxia caused by hypertension directly contributes to the development of CKD is demonstrated by angiotensin receptor blockers, angiotensin-converting enzymes, and the anti-oxidant tempol all normalizing renal oxygenation and function in hypertensive rats