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2010;48(7):95360 ( Curi R )

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Saffron also contributes to Nrf2 activation, reducing OS and inflammation in both the intestine and the brain

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This means that ferroptosis can induce other kinds of cell death, and/or it plays a minor effect in cell death, or we use inhibitors after the reversible point and once this threshold is exceeded, ferroptosis will be irreversible Recently, we also found that ferroptosis is vital for tumor immunity such as macrophage phagocytosis (71) and T cell killing (115) but the crosstalk between ferroptosis and the glioma immunosuppressive microenvironment is not clear