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In addition, insulin induced by GLP-1 may also promote ANP secretion (72)
However, constipation may persist longer and sometimes requires ongoing dietary or supplemental management throughout treatment
[PubMed: 8292469] 188
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Patients with IBS-C may tolerate tirzepatide's GIP effects better, while those with IBS-D might require lower-dose GLP-1 monotherapy or a shorter titration period
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