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The pivotal NEJM trial reported that the percentage of patients experiencing symptoms of growth hormone excess including joint pain, peripheral edema, and muscle aches was lower than seen in earlier large trials of growth hormone itself in HIV-infected patients
Fractions were concatenated (fraction 1+9, 2+10, ) into eight final fractions, dried and reconstituted in 100 L 10% ACN
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This is a sign of long-standing nerve compression and is a strong indication for surgical evaluation
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