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We also found another inhibitor of this reaction, the F1 peptide, which is more efficient than ethacrynic acid (55.1% activity with CDNB as a substrate, 81.2% activity with DCNB as a substrate)

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Connective tissue diseases include joint hypermobility syndrome, or the hypermobility spectrum disorder, Ehlers-Danlos syndrome, Marfan syndrome, osteogenesis imperfecta, Stickler syndrome