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"All four STEP trials did not include participants who had experienced major depressive disorder in the past two years or had bipolar disorder, schizophrenia, or other significant mental illness," Wadden told Newsweek

Their use is rising rapidly, and with good reason: These medications have been shown to reduce blood sugar, improve fatty liver, GERD, sleep apnea, osteoarthritis, blood pressure, triglycerides, major adverse cardiovascular events, and even show potential benefits for conditions like alcohol use disorder (Mozaffarian et al., 2025

If optimization does not produce results, combination therapy should be considered

Inspect before every dose: discard if cloudy, particulate, discolored, or unusual odor is present

May your metabolic health stay optimized, your weight management stay sustainable, and your supplement choices stay evidence-based.