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Budget neutrality is typically assessed against what projected federal expenditures would be without the waiver and is the subject of detailed negotiations between states and CMS

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Some studies of topical cream/lotion (2% GSSG) showed measurable effect

Jun 2021;19(6):493-504

Salcaprozate sodium (SNAC) is included as a delivery-support ingredient to help protect actives through the GI environment and support consistent oral uptake