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Risk factors include kidney dysfunction, liver disease, excessive alcohol intake, and acute conditions causing tissue hypoxia

The presence of these GLP-1-positive cells was consistent in rats with the mucosal expression of the key enzyme for proglucagon processing into GLP-1 (i.e., Pcsk1/3 coding for PC1/3) and of Pax6 , required for L cell differentiation (Supplementary Fig

Accumulation of succinate controls activation of adipose tissue thermogenesis

2021 Jun 29;12:627533

it has been shown to be an efficient inhibitor of Jun kinase (also known as stress-activated kinase), the enzyme that activates c-jun and several other transcription factors (Adler et al ., 1999)