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That means looking beyond the number on the scale and paying attention to markers like blood pressure, blood sugar, cholesterol, inflammation, and long-term cardiovascular risk

Both conditions can cause abdominal distension, cramping, severe constipation, nausea, vomiting, dehydration, and inability to pass gas or stool

What follows covers the three primary injection sites in detail, the science behind absorption differences between sites, step-by-step injection technique, a complete rotation schedule you can follow week by week, troubleshooting for common injection site problems, and the specific considerations that make retatrutide administration different from other GLP-1 receptor agonists

They were also a big part of why the dose is raised gradually: starting low and going slow meaningfully reduced how many people experienced them

What to expect: Mild appetite reduction starting around week 3