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It also slows down digestion, which helps to lower glucose levels in the blood further

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In a follow-up publication the next year, the Copenhagen group evaluated their isolated GLP-1 (736), along with synthetic GLP-1 (736) amide 4 from a commercial source, and reported modest (two to four-fold) increases in insulin production in the perfused pig pancreas when exposed to nanomolar concentrations of these peptides [45], a significant but less dramatic effect than the earlier MGH findings in rats [40]

Finally, we highlight the remaining challenges for NADs development, offering references for the design and clinical application of novel NADs