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So we dont have that same sort of rigour, if you like, on just overall safety. The third safety question is legal, and the answer differs by jurisdiction: United States

IGFBP-rP1 and IGFBP-rP2 have been reported to increase during senescence of the prostate epithelium and in response to growth inhibitors (TGF-1 and atRA) suggesting they are likely to negatively regulate growth, however the role of IGFBP-rP3 as a growth stimulator and/or protooncogene has been reported after preferential expression in cancerous cells [26]

The efficient depletion of gut microbiota after antibiotic treatment was confirmed by detection of bacterial 16S DNA (Supplemental Figure 1C)

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