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These factors extend the network of DAMPs signaling beyond the classical receptors and can further modulate immune cell responses in the postoperative period (for example, IL-33 can drive type 2 immunity and might aid in resolution of injury, whereas HMGB1 sustains inflammation and also promotes immunosuppression in late phases) (53)

Changes in circulating 25-hydroxyvitamin D according to vitamin D binding protein genotypes after vitamin D(3) or D(2)supplementation

Due to the unclear and complicated pathobiology of MS-related depression (3, 10), further clinical and experimental investigations are needed to clarify and understand the molecular mechanisms of depression origin in MS patients and provide effective and practical therapeutic approaches