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[11] [12] These cardiovascular benefits have influenced treatment algorithms, with guidelines recommending GLP-1 receptor agonists with proven cardiovascular benefit for patients with type 2 diabetes and atherosclerotic cardiovascular disease

The result is a gradual depletion of B12 stores that can take months to become clinically apparent but may cause fatigue , dizziness , and neurological symptoms long before a blood test catches the deficiency

The glucagon receptor component in retatrutide adds a variable not present in existing medications, making cardiovascular monitoring particularly important

doi:10.1055/s-2004-826160

PMC 4241798