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Another novel inflammatory cytokine is IL-33 which exerts its effects by binding to the orphan receptor suppression of tumorigenicity 2 (ST2), leading to the activation of various signaling pathways resulting in neuronal death (Sun et al

2.2 Underlying role of oxidative stress in neurodegeneration A large body of evidence demonstrates a particular susceptibility of neurons to ROS because of their distinctive characters: High energy demands, high oxygen consumption, high levels of iron, polyunsaturated fatty acids and, in particular, low anti-oxidative protection [8]

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Chem Biol Interact 188:4451 Edoardo G, Roberto T, Vincenzo S (2005) Liver enzyme alteration: a guide for clinicians

10.1186/s12974-018-1175-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 74.Agnoletti, D., Cicero, A