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Additional medical conditions, medications, or individual health factors may impact whether this therapy is appropriate
The inhibitory effect of GLP-1 on glucagon secretion in vivo was observed only when the blood glucose level was equal to or higher than the fasting level, at higher blood glucose levels, the inhibition of glucagon gradually increased (Holst, 2007), and when the blood glucose concentration was less than 3.7 m mol/L, GLP-1 lost its effect on inhibiting glucagon secretion (Nauck et al., 2002)
23 , e282e293 (2011)
Over time, skin stretches to accommodate higher weight, and with sudden fat loss, collagen and elastin fibers can struggle to provide the same snapback. Skin elasticity declines with rapid loss: Collagen and elastin break down faster than they can rebuild when fat disappears quickly, leaving skin looking looser or crepey