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The most reliable way to track efficacy is through periodic lab testing, specifically IGF-1 levels, which rise in response to increased GH secretion

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doi: 10.4103/1947-2714.170600 270

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Strikingly, a high number of proteins more than 80% from all models exhibited differential mean expression between control and cKOt mice (Figure 1J), demonstrating the substantial effect of Bmal1 deletion on the renal proteome