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This limits the affordability of many patients, especially from low- and middle-income groups and those who do not have medical insurance, restricting market growth

Scientists have long recognised the potential benefits of transdermal drug delivery, including improved patient compliance, steady drug release, and avoidance of gastrointestinal degradation and first-pass metabolism

reported two cases of depression associated with the use of semaglutide 19

Several mechanisms may potentially contribute to blood pressure effects, including: weight loss (a well-established factor in blood pressure reduction), possible promotion of natriuresis (sodium excretion by the kidneys), and theoretical improvements in endothelial functionthough many of these mechanisms remain hypothetical rather than definitively proven

More than 40% of respondents who have diabetes and about a quarter of those who have heart disease said they have used GLP-1 drugs