These tumours arise because the glp-1(gf) allele prevents proper GSC differentiation, such that when these cells reach the proximal gonad, where another notch ligand (APX-1) is present, they begin to proliferate again 22
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If you just want to inject the follistatin peptide directly (which is how these peptides are generally administered), then you would have to do it several times a day to keep levels elevated
VK2735 demonstrated encouraging safety and tolerability following 13 weeks of once-weekly dosing in the Phase 2 VENTURE study
