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There is no evidence to suggest that the fundamental mechanisms of action differ between sexes
10.1016/j.ajpath.2014.05.003 26
The most characterized transcription factors involved in the regulation of EMT include snail family transcriptional repressor (SNAIL)1, zinc finger E-box binding homeobox 1 (ZEB1), and twist family bHLH transcription factor 1 (TWIST1) [33, 34]
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The reductions in lean mass do not necessarily indicate pathological muscle loss, as improvements in body composition, physical function, and quality of life have been reported with semaglutide and tirzepatide in subanalyses of the STEP-1 and SURMOUNT-1 programs [7,8]
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