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Psychological & Behavioral Factors Stress eating, emotional triggers, late-night cravings, and lack of routine can slow progress, but GLP-1 helps regulate these over time

Currently available GLP-1 receptor agonists include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)

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They work through several important mechanisms: They increase insulin release from the pancreas when blood glucose is high They reduce excess glucose release from the liver They slow stomach emptying, helping prevent sharp glucose spikes after meals They increase feelings of fullness, often reducing appetite Because these effects depend on blood glucose levels, GLP-1 medications on their own carry a very low risk of causing low blood sugar (hypoglycaemia)

Dulaglutide sales surged starting in 2019 and became the top seller in GLP-1RA in 2020