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That dispute is what the litigation is designed to resolve

Here is how that breaks down by purpose

Start with a more moderate fasting window, such as 14:10 or 16:8, and adjust gradually

Warning signs that warrant immediate medical evaluation include: Decreased urine output or dark, concentrated urine Persistent nausea, vomiting, or diarrhea lasting more than 24 hours Dizziness, lightheadedness, or orthostatic symptoms suggesting volume depletion Unexplained fatigue or confusion which may indicate uremia Swelling of the legs, ankles, or face suggesting fluid retention Flank pain or blood in the urine (though rare with these medications) Emergency red flags include inability to keep fluids down for 4-6 hours, no urination for 12 hours, severe confusion, chest pain, or syncope

ET and WR worked on the data analysis and revisions of the manuscript