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Landmark clinical trials, such as the STEP programme for semaglutide published in The New England Journal of Medicine, have demonstrated that these medications can lead to average weight loss of 15% or more when combined with lifestyle changes, a level of efficacy previously achievable only through bariatric surgery

A limitation with MOMPOD was the study did not collect HbA1c information in the vast majority of the women before delivery, so it is not clear whether glycemic control was equivalent in both arms

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doi: 10.1007/s00394-012-0470-x 57 BhlerSFrahmJLiermannWTienkenRKerstenSMeyerUet al

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