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Synergistic interactions of N-3 PUFAs with multiple nuclear receptors, in particular PPAR- and RXR, might amplify VDR signaling further, as N-3 PUFAs promote PPAR-/PGC-1 pathways 115,116 and stabilize VDR-RXR heterodimers, which are critical for the VDR transcriptional activity 117,118

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These findings highlight its relevance in studying vascular signaling pathways and tissue regeneration processes

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