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These agents should not be used alone secondary to increases in plasma renin activity, cardiac output, and heart rate and should therefore be used only when -blockers and diuretics are part of the antihypertensive regimen

In terms of statistical analysis, we followed two main approaches

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Long-acting gut-hormone agonists as a class tend to show tachyphylaxis of the gastric-emptying effect it attenuates with continued dosing even as central appetite suppression persists