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In septic lung injury, elevated lactate levels exacerbate alveolar epithelial cell ferroptosis through lactylated histone H3 lysine 18 (H3K18la)-mediated upregulation of METTL3, which enhances m6A modification of ACSL4, ultimately contributing to the development of acute respiratory distress syndrome (82)

Studies have also shown that the lentivirus vector confers moderate inflammatory risk, but further studies in immunogenicity and prevention of recombination events are needed for optimized clinical translation [146]

GCLM: Glutamate-cysteine ligase modifying subunit