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Frondoside A downregulates Bcl-2 and survivin, increases ROS production, and promotes cytochrome c release, ultimately triggering mitochondrial apoptosis c release, ultimately triggering mitochondrial apoptosis (127)

Oxidative stress: the role of antioxidant phytochemicals in the prevention and treatment of diseases

Using DHEA over a long period or at high doses may be associated with cancer, and short-term use at low doses may lead to side effects such as acne, insomnia, mood changes, headache, and stomach upset

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doi: 10.1056/NEJMoa072375 126 PandyaNDeMott-FribergRBowersCYBarkanALJaffeCA