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Food and Drug Administration (FDA) approved oral semaglutide in September 2019 for use in adults with type 2 diabetes

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While data specific to GLP-1 RA discontinuation remain limited, a large-scale prospective study on weight cycling (mean age 63.6 years, at high risk of T2DM) reported that weight regain was typically characterized by an adverse shift in body composition, with FM returning to baseline levels while FFM declined by 1.50 kg (95% CI 0.662.35)

Scarring is the primary consideration, as arm lift scars are typically visible when arms are raised, though most patients find the improved contour worth this trade-off