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Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception
The companys CEO Alex Oshmyansky has been explicit about the mechanism: for a drug like imatinib, a highly expensive chemotherapy, 99% of the sticker price goes directly to PBMs, not to the manufacturer
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Regular kidney function monitoring through blood tests is essential, particularly for patients with pre-existing kidney problems
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