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At the cellular level, vitamin B12 is involved in DNA synthesis and neuroprotection, acting as a cofactor for enzymes critical to these processes, such as methionine synthase and methylmalonyl-CoA mutase (72, 73)
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Additionally, ARA 290 has been shown to reverse diabetes-induced autonomic nerve degeneration in a murine model (12)
Additionally, Vlasits et al
however, the generally accepted model is that after ligand binding to LRP1, the ligandLRP1 complex is taken up into early endosomes ( +/+ HepG2 cells, ICC data show that HPX moves into two populations of endosomes (Figure 4)
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