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doi: 10.3389/fcell.2021.646113 Received 25 December 2020 Accepted 09 June 2021 Published 07 July 2021 Volume 9 - 2021 Edited by Rossella Rota, Bambino Ges Childrens Hospital Scientific Institute for Research, Hospitalization and Healthcare, (IRCCS), Italy Reviewed by Jing Yang, University of South China, China